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ea0029p1176 | Obesity | ICEECE2012

Brown rice and its component, γ-oryzanol, attenuate the preference for dietary fat by decreasing hypothalamic endoplasmic reticulum stress in mice

Kozuka C. , Yabiku K. , Sunagawa S. , Ueda R. , Taira S. , Ikema T. , Yamakawa K. , Higa M. , Shimabukuro M. , Masuzaki H.

It is known that brown rice (BR) prevents obesity and type 2 diabetes in humans. Previous studies have shown that exaggerated endoplasmic reticulum (ER) stress in the hypothalamus of obese mice is linked to hyperphagia. Here we tested the hypothesis that BR might decrease ER stress in hypothalamus, leading to the attenuation the preference for dietary fat.Eight-week-old mice were randomly divided into three groups: the control, BR-containing diet, and th...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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